Is acetaminophen acidic or basic?
Aciditity. Paracetamol (acetaminophen) is a weak acid. The equilibrium position lies very far to the left. The vast majority of paracetamol molecules in an aqueous solution will be found as the undissociated paracetamol molecules.
What is the solubility of acetaminophen?
Water
AcetoneAlcohol
Acetaminophen/Soluble in
What is the literature value for the melting point of paracetamol?
169-1 71 “C
Pure paracetamol is a white crystalline solid which melts at 169-1 71 “C.
What is the pH of acetaminophen?
Acetaminophen is an odorless, slightly bitter taste white crystalline powder. It is soluble in organic solvents such as methanol and ethanol but slightly soluble in water and ether. It’s pH range is 5.5 – 6.5 based on saturated aqueous solution.
What is the pKa of acetaminophen?
(8). Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical problem….Structure for T3D2571: Acetaminophen.
| Property | Value | Source |
|---|---|---|
| logP | 0.91 | ChemAxon |
| logS | -1.6 | ALOGPS |
| pKa (Strongest Acidic) | 9.46 | ChemAxon |
| pKa (Strongest Basic) | -4.4 | ChemAxon |
What is the best solvent for acetaminophen?
Acetaminophen is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas.
Is acetaminophen highly soluble in water?
Acetaminophen is a common low water-soluble drug whose solubility could be increased using various methods, including addition of a pharmaceutical cosolvent.
What is the boiling point of acetaminophen?
788°F (420°C)Acetaminophen / Boiling point
Is paracetamol and acetaminophen the same?
Acetaminophen is the United States adopted name,4 and in the United States the substance is always and only called acetaminophen. Paracetamol is the recommended international non-proprietary name,4 the British approved name,4 and the name used for the substance throughout the world outside the United States.