What is amiodarone pharmacokinetics?
PHARMACOKINETICS. Amiodarone is an iodine-containing compound with some structural similarity to thyroxine. The drug’s high iodine content likely is a factor in its effects on the thyroid gland. The bioavailability of amiodarone is variable but generally poor, ranging from 22 to 95 percent.
What is the property of amiodarone?
Amiodarone is an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period.
What is amiodarone 200mg?
Amiodarone is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. This medicine is used in patients who have already been treated with other medicines that did not work well.
What classification is amiodarone?
Amiodarone is in a class of medications called antiarrhythmics. It works by relaxing overactive heart muscles.
Is amiodarone an anticoagulant?
Background: Direct oral anticoagulants (DOACs) and amiodarone are widely used in the treatment of nonvalvular atrial fibrillation. The DOACs are P-glycoprotein (P-gp) and cytochrome p-450 (CYP3A4) substrates.
What is Cordarone 200mg?
Cordarone ® X 100mg and 200mg Tablets It works by controlling the uneven beating of your heart (called ‘arrhythmias’). Taking the tablets helps your heartbeat to return to normal. Cordarone X Tablets can be used to: Treat uneven heartbeats where other medicines either have not worked or cannot be used.
Is 200 mg of amiodarone a lot?
Low-dose amiodarone (100-300 mg per day) is effective for a wide variety of ventricular and supraventricular arrhythmias, including as part of a rhythm control strategy for patients with atrial fibrillation, especially when structural heart disease is present.
Is amiodarone a rate or rhythm control?
Amiodarone is the drug recommended for rate control of AF with rapid ventricular response in patients with chronic heart failure in whom beta-blockers cannot be administered. Amiodarone shows little negative inotropic effect and can be used in patients with reduced left ventricular function.
Why does amiodarone cause hypotension?
In the acute setting, amiodarone can cause hypotension due to vasodilation and depression of myocardial contractility; this may be partly due to the solvent, polysorbate 80 or benzyl alcohol, used to assist in dissolving the drug [6–8].
What is the drug classification of amiodarone and what is it used to treat?
Amiodarone is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a certain type of abnormal heart rhythm when other medications did not help or could not be tolerated. Amiodarone is in a class of medications called antiarrhythmics.
Why am I taking amiodarone?
asthma or another lung disorder;
What is the chemical structure of amiodarone?
Chemical Class: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4- [2- (diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular d rug used for the treatment of cardiac dysrhythmias.
Does amiodarone HCl interact with other medications?
There are a number of important drug interactions with amiodarone. This agent appears to have a marked effect on the kinetics of some commonly used cardiovascular drugs, such as warfarin, digoxin, quinidine, and procainamide, and has dynamic interactions with others, such as the beta blockers and so …
Does amiodarone is compatible with metronidazole?
The most common medications related to these DDIs were ondansetron, amiodarone, metronidazole, and haloperidol. Conclusion: DDIs may be a significant cause of QT prolongation in cardiac ICUs. These data can be used to educate clinicians on safe medication use.