Is CD81 a receptor?

Is CD81 a receptor?

HCV-E2 engaged CD81 is only 30% internalized after 12hr, suggesting CD81 may be primarily an attachment receptor for HCV. It also appears to play a role in liver invasion by Plasmodium species.

What does CD81 bind to?

The HCV envelope protein E2 binds human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes.

What is CD81 ligand?

CD81 is a widely expressed cell surface protein that that has been mentioned previously as a cellular coreceptor for ligation of HCV to the hepatocyte. This receptor is also present on most if not all cells of the immune system.

How many cluster of differentiation are there?

Since then, its use has expanded to many other cell types, and more than 320 CD unique clusters and subclusters have been identified.

What is CD20 function?

CD20 is a membrane-embedded surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.

Is CD28 the T cell receptor?

CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.

What is CD3 and CD28?

CD3 and CD28, a costimulation signal essential for cell activation. In this report, we show that these two receptor systems provide. complementary functions in regulating the cellular forces needed. to test the mechanical properties of the extracellular environment.

What are CD markers used for?

The CD system is commonly used as cell markers; this allows cells to be defined based on what molecules are present on their surface. These markers are often used to associate cells with certain immune functions or properties.

What does CD81 stand for?

CD81 molecule, also known as CD81 ( C luster of D ifferentiation 81 ), is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1 ( T arget of the A nti p roliferative A ntibody 1), and Tetraspanin-28 (Tspan-28).

How does CD81 interact with T cells?

Engagement of CD81 lowers the signaling threshold required to trigger T-Cell\\CD3 mediated proviral DNA in CD4+ T cells. CD81 appears to play a role in the pathogenesis of influenza. CD81 has been shown to interact with TSPAN4, CD19, CD9, PTGFRN, CD117 and CD29. Benzyl salicylate and terfenadine have been shown to bind to CD81.

Is CD81 an attachment receptor for human hepatocellular virus (HCV)?

HCV-E2 engaged CD81 is only 30% internalized after 12hr, suggesting CD81 may be primarily an attachment receptor for HCV. It also appears to play a role in liver invasion by Plasmodium species. CD81 is required for Plasmodium vivax sporozoite entry into human hepatocytes and for Plasmodium yoelii sporozoite entry into murine hepatocytes.

What is the role of tetraspanin CD81 in immunodeficiency?

“Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB]